Figure 4. Plot shows absolute effects of placebo and salmeterol on response to exercise over time. Morning baseline data were recorded after administration of study drugs. Values are mean ± SE. (Reproduced by permission of the publisher from: Nelson JA, Strauss L, Skowronski M, Ciufo R, Novak R, McFadden ER Jr. Effect of long-term salmeterol treatment on exercise-induced asthma. N Engl J Med 1998;339:144.10)