Clinical Contributions

This is a selective update of recent breakthroughs in a spectacularly active field. Topics briefly considered include the genome project, gene chips, diagnosis and prevention, pharmacogenomics, cloning, stem cell therapy, vitamins and birth defects, preimplantation diagnosis and therapy, and transgenic therapy.
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Clinical Management for Survivors of Sudden Cardiac Death
Michael R Lauer, MD, PhD

Death by cardiac arrest is potentially preventable in many cases and, thus, remains a major public health problem in the United States. The most common mechanism of reversible and preventable cardiac arrest is ventricular fibrillation. This article reviews clinical and electrophysiological aspects of cardiac arrest with emphasis on the use of the implantable cardioverter-defibrillator in survivors.
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Kaiser Permanente Medicine 50 Years Ago: Migraine, Histamine, Allergic and Other Related Cephalgias
Thurman B Dannenberg, MD;
Commentary by Joel S Richmon, MD

The reprinted 57-year-old article by an early Kaiser Permanente physician about migraine describes clinical features, as well as the limited information then available about etiology and treatment. The accompanying current Commentary describes some current concepts about this common and still incompletely understood condition.
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