Figure 2. Meta-analysis showing mortality risk associated with antiarrhythmic drugs, presumably secondary to proarrhythmic effects exerted by these agents. Only b-adrenergic blockers and amiodarone appear to reduce risk. Bars indicate 95% confidence intervals; areas of squares are proportional to variance for each drug trial or group of trials.

(Adapted and reproduced with the permission of the publisher and author from: Teo KK, Yusuf S, Furberg CD. Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction: an overview of results from randomized control led trials. JAMA 1993 Oct 6;270(13):1589-95, Figure 1.)⁵⁸